--- /dev/null
+; NOTE: Assertions have been autogenerated by utils/update_llc_test_checks.py
+; RUN: llc < %s -mtriple=x86_64-- -mattr=avx | FileCheck %s
+
+; FIXME: Eliminating a shuffle means we have to replace an undef operand of a horizontal op.
+
+define void @PR43225(<4 x double>* %p0, <4 x double>* %p1, <4 x double> %x, <4 x double> %y, <4 x double> %z) nounwind {
+; CHECK-LABEL: PR43225:
+; CHECK: # %bb.0:
+; CHECK-NEXT: vmovaps (%rdi), %ymm0
+; CHECK-NEXT: vmovapd (%rsi), %ymm0
+; CHECK-NEXT: vhsubpd %ymm0, %ymm2, %ymm0
+; CHECK-NEXT: vmovapd %ymm0, (%rdi)
+; CHECK-NEXT: vzeroupper
+; CHECK-NEXT: retq
+ %t39 = load volatile <4 x double>, <4 x double>* %p0, align 32
+ %shuffle11 = shufflevector <4 x double> %t39, <4 x double> %x, <4 x i32> <i32 1, i32 5, i32 3, i32 7>
+ %t40 = load volatile <4 x double>, <4 x double>* %p1, align 32
+ %t41 = tail call <4 x double> @llvm.x86.avx.hadd.pd.256(<4 x double> %shuffle11, <4 x double> %t40)
+ %t42 = tail call <4 x double> @llvm.x86.avx.hsub.pd.256(<4 x double> %z, <4 x double> %t41)
+ %shuffle12 = shufflevector <4 x double> %t42, <4 x double> undef, <4 x i32> <i32 0, i32 0, i32 2, i32 2>
+ store volatile <4 x double> %shuffle12, <4 x double>* %p0, align 32
+ ret void
+}
+
+declare <4 x double> @llvm.x86.avx.hadd.pd.256(<4 x double>, <4 x double>)
+declare <4 x double> @llvm.x86.avx.hsub.pd.256(<4 x double>, <4 x double>)